02826472 is referenced by 11 patents.

The present invention relates to an isolated mutant eubacterium comprising at least one mutation resulting in a substitution of at least one amino acid in the beta-subunit of the RNA-polymerase encoded for by the rpoB-gene providing an altered production of a product of interest when said production of a product of interest is compared to the production of the same product in an isogenic wild type strain grown at identical conditions, wherein the substitution of at least one amino acid occurs at any of the positions 469, 478, 482, 485, or 487 of SEQ ID NO:2, or at the equivalent positions in any eubacterial RNA-polymererase beta-sub-unit family member. Another aspect of the invention relates to a process for producing at least one product of interest in a mutant eubacterium and to a use of the mutant eubacterium according to the invention for producing at least one product of interest.

Title
Eubacterial rna-polymerase mutants with altered product production
Application Number
02826472
Publication Number
1610740
Application Date
December 20, 2002
Publication Date
April 27, 2005
Inventor
Nielsen Preben
Banke Niels
Andersen Jens Toenne
Jorgensen Steen Troels
Agent
wu xiaonan bian xinqin
Assignee
Novozymes
IPC
C12N 09/12